Anti-GIPC1 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Application

Anti-GIPC1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

GIPC PDZ domain containing family, member 1 (GIPC1) is a protein encoded by the GIPC1 gene in humans. The mammalian GIPC1 consists of a central PDZ domain and a C-terminal acyl carrier protein (ACP) domain. It is an essential adaptor protein of receptors that plays an important role in cancer progression and therapy resistance. The GIPC1 cytoplasmic scaffold protein interacts with numerous receptor signaling complexes and plays a role in tumorigenesis. It is highly expressed in a number of human malignancies that include breast, ovarian, gastric and pancreatic cancers. GIPC1 inhibition may be a new target for therapeutic development for the treatment of human cancers. It is a breast cancer-associated immunogenic antigen that is overexpressed in breast cancer.

Immunogen

Recombinant regulator of G-protein signalling 19 interacting protein 1 isoform 1

Immunogen Sequence: GI # 5031715, sequence 1-333

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.